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Human papillomavirus (HPV)-positive oropharyngeal cancer (OPC) also known as HPV16+ oropharyngeal cancer or HPV+ OPC is a recognized subtype of oropharyngeal squamous cell carcinomas (OSCC),〔 associated with the HPV type 16 virus. ==Causes== HPV oral infection precedes the development of HPV+ OPC.〔 Slight injuries in the mucous membrane serve as an entry gate for HPV, which thus works into the basal layer of the epithelium.〔 People testing positive for HPV16 oral infection have a 14 times increased risk of developing HPV+ OPC.〔 Immunosuppression seems to be an increased risk factor for HPV+ OPC.〔 Individuals with TGF-β1 genetic variations, specially T869C, are more likely to have HPV16+ OPC. TGF-β1 plays an important role in controlling the immune system. A 1993 study has found that patients with human papillomavirus (HPV)-associated anogenital cancers had a 4.3-fold increased risk of tonsillar squamous-cell carcinoma. Although evidence suggests that HPV16 is the main cause of OPC between non-smokers and non-drinkers, the degree to which tobacco and/or alcohol use may contribute to increase the risk of HPV+ OPC is unclear.〔 Concomitant human herpesvirus-8 infection can potentiate the effects of HPV-16. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「HPV-positive oropharyngeal cancer」の詳細全文を読む スポンサード リンク
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